A number of last-minute withdrawals proved costly for the visitors, but they still pushed the hosts and were only one behind (13-12) at the end of the third.
Alan Wollaston troubled Guildford’s defence all night as he superbly led Enfield’s attack and returned home with a six-goal haul.
Alex Waller, Nikos Chamalidis, Costas Chamalidis and Chris Dunn all found the net twice and it was only in the final quarter that Guildford managed to pull away.